Effects of Life-Long Supplementation of Potassium Nitrate on Male Mice Longevity and Organs Pathology

Many short-term studies with dietary nitrate supplementation in humans and animal models reported positive effects on the cardiovascular system, exercise efficiency, immune function. However, there has been long-standing concern related to cancer adverse hormonal effects. We studied long-term of different potassium (KNO3) concentrations laboratory mice longevity structural changes their organs. Four groups male were treated 0 mg (0%), 45 (1%), 90 (2%), 140 (3%) KNO3 drinking water. The monitored for agility health status daily. lifespan organ pathological analyzed. found no detrimental life-long survival treatment groups. Nitrate was associated a lower level (p = 0.002). conclude that had carcinogenic effect possibly prevented organs from aging.